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KMID : 1036020140030010029
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지질.동맥경화학회지
2014 Volume.3 No. 1 p.29 ~ p.37
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Abdominal and Pericardial Fat in Patients with and without Coronary Artery Disease: Computed Tomography Study
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Sohn Gwan-Hyeop
Kim Dong-Woon
Kim Sang-Min
Lee Sang-Yeub
Bae Jang-Whan
Hwang Kyung-Kuk
Kim Sung-Mok
Choe Yeon-Hyeon
Park Jung-Euy
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Abstract
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Objective: There has been a limited investigation looking into the correlation between pericardial fat and abdominal fat with coronary artery disease (CAD) as measured by coronary computed tomographic angiography (CCTA). We proposed that the volume of pericardial fat is larger in patients with CAD than in patients without CAD, and sought to determine which abdominal adiposity index best correlated with pericardial fat volume.
Methods: Participants were examined using CCTA between October 2007 and January 2008. All participants had no previous history of CAD. Pericardial adipose tissue (PAT) volume, abdominal total adipose tissue volume, abdominal subcutaneous adipose tissue volume, and abdominal visceral adipose tissue (AVAT) volume were measured using CCTA.
Results: Fifty patients (26.5%) demonstrated CAD, and 139 patients did not demonstrate CAD by CCTA. PAT volume in patients with CAD was larger than that of patients without CAD (173.2±64.2 cm3 vs. 147.6±50.4 cm3,p<0.01). However, indices of abdominal adiposity were not significantly different between the two groups. Using multivariable analysis, independent predictors of CAD were PAT volume (odds ratio [OR] 1.01, 95% confidence interval [CI] 1.00-1.02, p=0.04), coronary artery calcium score (OR 1.01, 95% CI 1.00-1.01, p<0.01), and typical chest pain (OR 4.88, 95% CI 1.47-16.21, p=0.01). AVAT volume showed a linear correlation with PAT volume.
Conclusions: PAT volume was an independent predictor of CAD as measured by CCTA. PAT volume was also well correlated with the AVAT volume among the indices of abdominal adiposity.
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KEYWORD
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Pericardial adipose tissue, Abdominal visceral adipose tissue, Abdominal subcutaneous adipose tissue, Computed tomography, Coronary artery disease
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